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Study: Pomegranate-Derived Compound May Address Heart Failure With Preserved Ejection Fraction
Kings College London, October 21 2026 (Natural News)
Researchers at King's College London have reported that urolithin A, a compound produced after gut bacteria digest foods including pomegranates, walnuts and berries, improved measures of heart function in animal models of heart failure with preserved ejection fraction and in engineered human heart tissue.
A particular type of heart failure affects more than 3 million people. Heart failure with preserved ejection fraction occurs when the heart still pumps blood but struggles to relax and properly fill. The study tested the compound in animals and in engineered human heart tissue.
The compound activates a protein called PKGl?, which promotes relaxation of blood vessels and the heart muscle.
The compound also significantly improved heart function in human heart tissue engineered from stem cells, suggesting the effects in animal hearts could translate to humans. A separate account of the findings described the compound as improving heart function in animal models of HFpEF and in engineered human heart tissue.