TWiV 1373: Challenging Dengue and RIGging Flu

TWiV explains results of a dengue virus human challenge which reveals that preexisting immunity shapes viral replication and broadly protective responses, and how influenza virus antagonizes self-sensing by RIG-I to enhance viral replication. Hosts: Vincent Racaniello, Alan Dove, Kathy Spindler, and Brianne Barker Subscribe (free): Apple Podcasts, RSS, email Become a patron of TWiV! Links for this episode Support science education at MicrobeTV Democratic doctors win big in 2026 midterm elections (CIDRAP) Florida’s dengue total jumps to 485 (CIDRAP) Dengue virus human challenge study (Sci Transl Med) Influenza virus and self sensing of host by RIG-I (Cell Rep) Letters read on TWiV 1373 Timestamps by Jolene Ramsey. Thanks! Picks of the Week Brianne – Five Science-Backed Benefits of ‘grandma hobbies’ Kathy – Bird of the Week from Ben Tonelli Alan – The Dark Frontier, by Jeffrey Marlow Vincent – Where Do Photons Actually Go When You Turn Off The Light? Intro music is by Ronald Jenkees Send your virology questions and comments to twiv@microbe.tv Content in this podcast should not be construed as medical advice.